A World’s First Multi-Layered Mechanism of Action
Recce’s anti-infectives are wholly synthetic and based on a patented polymeric structure and have been designed to overcome resistance. Traditional antibiotics inhibit a single target such as bacterial gyrase enzymes, cell wall biosynthetic enzymes, or enzymes required for DNA replication during bacterial cell division. They operate on a ‘lock and key’ mechanism and therefore only bind to a few active sites on the bacterial target. However, if a mutation is introduced into the target site, then the antibiotic will cease to be effective.
The Science
Behind R327
STAGE 1
R327 targets and irreversibly bind to essential bacterial proteins
STAGE 2
R327 interferes with bacterial cellular metabolism and energy production at or near the cell surface, depleting ATP
STAGE 3
R327 kills bacteria rapidly without inducing cell lysis
STAGE 4
R327 is rapidly and irreversibly bactericidal
A Multi-Layered Mechanism of Action
R327 activity against Escherichia coli
R327 activity against Staphylococcus aureus
Without R327
R327 (3,000 ppm)
- R327 at 3,000 ppm shown to be highly effective against E. coli - not allowing it to divide and grow.
- Healthy eukaryotic cells remain unaffected and continue to grow.
- R327 rapidly and irreversibly shuts down the ATP in E. coli.
Without R327
R327 (2,300 ppm)
- R327 at 2,300 ppm shown to be highly effective against S. aureus - not allowing it to divide and grow.
- Healthy eukaryotic cells remain unaffected and continue to grow.
- R327 rapidly and irreversibly shuts down the ATP in S. aureus.
R327 works to kill bacteria ‘unlike any antibiotic ever seen’ with multiple mechanisms of action. R327 is rapidly and irreversibly bactericidal against Gram-negative E. coli bacteria in both active and stationary phase cell with the potential to outperform the best in class commercial antibiotics.
A Multi-Layered Mechanism of Action
R327 activity against Escherichia coli
Without R327
R327 (3,000 ppm)
- R327 at 3,000 ppm shown to be highly effective against E. coli without affecting growing, healthy eukaryotic cells.
- R327 rapidly and irreversibly shuts down the ATP in E. coli, not allowing it to divide and grow.
R327 activity against Staphylococcus aureus
Without R327
R327 (2,300 ppm)
- R327 at 2,300 ppm shows to be highly effective against S. aureus without affecting growing, healthy eukaryotic cells.
- R327 rapidly and irreversibly shuts down the ATP in S. aureus, not allowing it to divide and grow.